Tramadol is used for:

- Treating moderate to moderately severe pain.

- Tramadol is an analgesic. It works in certain areas of the brain and nervous system to decrease pain.

Do NOT use Tramadol if:

• you are allergic to any ingredient in Tramadol
• you have had a severe allergic reaction (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue) to codeine or other opioids (eg, morphine)
• you are intoxicated with alcohol, other opioids or narcotics (eg, codeine, morphine), sedatives or sleeping medicines (eg, temazepam, zolpidem), or other medicines
• you have severe liver or kidney problems
• you are taking carbamazepine, nefazodone, sodium oxybate (GHB), a thioxanthene (eg, thiothixene), or another product that contains tramadol

Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription (especially depression medicines) or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have liver, kidney, or thyroid problems; a blockage in the bladder; diabetes; heart problems; high blood pressure; prostate problems; or metabolism problems
• if you have or recently have had any head injury, brain injury or tumor, increased pressure in the brain, or infection of the brain or nervous system
• if you have a history of diarrhea caused by antibiotic use, recent stomach or bowel surgery, or any other stomach or bowel problems (eg, pain, inflammation, ulcers)
• if you have a history of lung or breathing problems (eg, asthma, chronic obstructive pulmonary disease [COPD]) or a seizure disorder (eg, epilepsy)
• if you are going through withdrawal from alcohol or other substances or if you have a history of alcohol or other substance abuse, mood or mental problems (eg, depression), or suicidal thoughts or actions

Some MEDICINES MAY INTERACT with Tramadol . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Azole antifungals (eg, ketoconazole), linezolid, lithium, macrolide antibiotics (eg, erythromycin), nefazodone, quinidine, selective serotonin and norepinephrine reuptake inhibitors (SNRIs) (eg, duloxetine), selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine, paroxetine), St. John's wort, tricyclic antidepressants (eg, amitriptyline), or triptans (eg, sumatriptan) because serotonin syndrome may occur
• Anorexiants (eg, phentermine), buytrophenones (eg, haloperidol), certain medicines for mental or mood disorders (eg, olanzapine), cyclobenzaprine, furazolidone, loxapine, monoamine oxidase inhibitors (MAOIs) (eg, phenelzine, selegiline), molindone, other opioid pain medicine (eg, codeine, hydrocodone), phenothiazines (eg, promethazine), sodium oxybate (GHB), thioxanthenes (eg, thiothixene), or tiagabine, because the risk of side effects, including excessive drowsiness, trouble breathing, liver problems, or seizures, may be increased
• Other products containing tramadol because they may increase the risk of Tramadol 's side effects
• Rifampin because it may decrease Tramadol 's effectiveness
• Carbamazepine because it may decrease Tramadol 's effectiveness; the risk of seizures may also be increased
• Anticoagulants (eg, warfarin) or digoxin because the risk of their side effects may be increased by Tramadol

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tramadol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.